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Index > Protein center > Muc2(Gene name) > Mouse
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  • Muc2 (Gene name),
  • Mucin-2 (Protein name ),  MUC2_MOUSE from NCBI database.
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  • Gene name:
    Muc2;
    Protein name:
    Mucin-2(MUC-2);
    Alternative:
    Secreted gel-forming mucin;Colonic mucin(MCM);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization (By similarity). Interacts with FCGBP. Interacts with AGR2; disulfide-linked.
    Function:
    Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
    Subcellular Location:
    Secreted In the intestine, secreted into the inner and outer mucus layers.
    Protein Attributes:
    Sequence length:
    2680
    Sequence:
    50:
    MGLPLARLVA | ACLVLALAKG | SELQKEARSR | NHVCSTWGDF | HYKTFDGDVY | 
    100:
    RFPGLCDYNF | ASDCRDSYKE | FAVHLKRGLG | EAGGHSQIES | ILITIKDDTI | 
    150:
    YLTHKLAVVN | GAMVSTPHYS | SGLLIEKNDA | YTKVYSRAGL | SLMWNREDAL | 
    200:
    MVELDSRFQN | HTCGLCGDFN | GMQTNYEFLS | EEGIQFSAIE | FGNMQKINKP | 
    250:
    EVQCEDPEAV | QEPESCSEHR | AECERLLTSA | AFEDCQTRVP | VESYVRACMH | 
    300:
    DRCQCPKGGA | CECSTLAEFS | RQCSHAGGRP | ENWRTASLCP | KKCPNNMVYL | 
    350:
    ESSSPCVDTC | SHLEVSSLCE | EHYMDGCFCP | EGTVYDDITG | SGCIPVSQCH | 
    400:
    CKLHGHLYMP | GQEFTNDCEQ | CVCNAGRWVC | KDLPCPETCA | LEGGSHITTF | 
    450:
    DGKKFTFHGD | CYYVLTKSEH | NDSYALLGEL | ASCGSTDKQT | CLKTVVLLTD | 
    500:
    DKKNVVAFKS | GGSVLLNEME | VTLPHVAASF | SIFQPSSYHI | VVNTKFGLRL | 
    550:
    QIQLLPVMQL | FVTLDQAAQG | QVQGLCGNFN | GLESDDFMTS | GGMVEATGAG | 
    600:
    FANTWKAQSS | CHDKLDWLDD | PCSLNIETNY | AEHWCSLLKR | SETPFARCHL | 
    650:
    AVDPTEYYKR | CKYDTCNCQN | NEDCMCAALS | SYARACAAKG | VMLWGWRERV | 
    700:
    CNKDVHACPS | SQIFMYNLTT | CQQTCRSLSE | GDSHCLKGFA | PVEGCGCPDH | 
    750:
    TFMDEKGRCV | PLAKCSCYHH | GLYLEAGDVI | LRQEERCICR | NGRLQCTQVK | 
    800:
    LIGHTCQYPK | ILVDCNNLTA | LAVRKPRPTS | CQTLVAGYYH | TECISGCVCP | 
    850:
    DGLLDDGRGG | CVEEDKCPCI | HNKDLYSSGE | SIKLDCNNTC | TCQKGRWECT | 
    900:
    RYACHSTCSI | YGSGHYITFD | GKHYDFDGHC | SYVAVQDYCG | QNSTGSFSII | 
    950:
    TENVPCGTTG | VTCSKAIKIF | IGGTELKLVD | KHRVVKQLEE | GHHVPYITRE | 
    1000:
    VGQYLVVEAS | SGIIVIWDKK | TTIFIKLDPS | YKGTVCGLCG | NFDDQTKNDF | 
    1050:
    TTRDHMVVTS | ELDFGNSWKE | ASTCPDVSHN | PDPCSLNPHR | RSWAEKQCSI | 
    1100:
    IKSRVFKVCH | SKVDPTVFYE | ACVHDSCSCD | TGGDCDCFCS | AVASYAQECT | 
    1150:
    KAEACVFWRT | PDLCPIFCDY | YNPPDECEWH | YEPCGNRSFE | TCRTLNGIHS | 
    1200:
    NISVSYLEGC | YPRCPEDRPI | YDEDLKKCVT | GDKCGCYIED | TRYPPGGSVP | 
    1250:
    TDEICKSCTC | TNTSKIECHP | DEGKILNMTQ | DGIFCYWEFC | GPNGTVGQHF | 
    1300:
    NICGSSTAIP | STTTSFTTIS | TPISTTPIST | TITTTTVTMT | TEQVPCCFWS | 
    1350:
    DWINKYHPTK | ENGGDRETFT | HVCSAPEDIE | CRAATDPKLS | WEELGQKVQC | 
    1400:
    NVSTGLICNN | EDQYGIGEFE | LCYDYEIRVN | CCYPMEYCTP | STISPTTSTT | 
    1450:
    TLSTTPPTSS | PTTLPTSSPV | TSSATLPTTS | SITSTISPTT | SPSTATQTIS | 
    1500:
    VTTSQTSSSA | TPPNSSPTSS | ATTSPTTSSG | TSTATSPSTS | PTTSSTFTTP | 
    1550:
    PSTTCIDDCK | WTGWLDSGKP | TYDIKSGDFE | LIKGVCEPHW | EVQNISCRAV | 
    1600:
    MHSNIPLDQL | GQIVVCNKEV | GLVCKNEDQE | IGGIIPMRMC | LNYEINVYCC | 
    1650:
    NPICFTSTPS | STTTETPTTT | STTKTSILTS | TTTQTPSPSP | TTTVTPTPAP | 
    1700:
    TTTQIPTSTS | TTTQTTTPTP | ITETSTPTST | ISQTPSPAST | TTVTPATTST | 
    1750:
    TTETSTSTST | TTQTTSPTPT | VTETSTPRST | TTQTPSPVPT | TTVTSTPTPT | 
    1800:
    IGETTTPKRP | PSTSTPTSFT | VPTETTTQTR | PLSTTPTTLE | TTRTSSWGTF | 
    1850:
    SSTSPITSPS | TVWTHTETQV | TCCVLNEMFY | GPGELVYNST | HGGTCFYVNC | 
    1900:
    SLDCHLQFFN | WSCPSTPSTP | TPSTPTPTPS | QTTTPSTTSS | KSTPSTPQST | 
    1950:
    SPKSTLSTPT | KTTPYGCPDF | DPPRQVNETW | WLCNCTMAIC | NHDNVVEIVP | 
    2000:
    LKCDPPPMPT | CANGLKPVRV | PDADNCCWHW | ECDCYCTGWG | DPHFVTFDGL | 
    2050:
    YYSYQGNCTY | VLVEEITPTV | DNFGVYIDNY | HCDANDKVSC | PRTLIVRHET | 
    2100:
    QEVQIKTVRM | MPIEVEVQVN | KQLVALPYKK | YGLEVYESGI | NIVVNISRLE | 
    2150:
    AKISYNGLSF | SIRLPYKLFV | NNTKGQCGTC | TNNTADDCIL | PSGKIISDCE | 
    2200:
    IAADEWLVND | PSKPHCPHKG | LTTKRPATTT | PGLSLNNCTV | SPVCHLIMDS | 
    2250:
    LFSQCHAFVP | PKHYYEACLF | DSCYVPGSNM | ECASVQAYAT | LCAKEGVCID | 
    2300:
    WRNHTQGVCS | VKCPPHKQYQ | ACGPEEEPTC | QPSSSQNSTL | LVEGCFCPEG | 
    2350:
    TTKFAPGYDV | CVKTCGCVGP | DNVPREFGEH | FEFDCKDCVC | REGGSGIVCQ | 
    2400:
    PKKCSGGNQT | TCEEDGTYLV | VETNPDDKCC | NITSCKCDTK | RCKAERPTCL | 
    2450:
    LGFEVKTEIV | PGKCCPVYSC | VPKGVCVHQN | AEYQPGSPVY | SNKCQDCVCT | 
    2500:
    NILDNSTQLN | VISCTHVPCN | ISCSSGFELV | DVPGECCKKC | QQTHCIIEGP | 
    2550:
    KQQYIILKPG | EIHKNPSNKC | TFFSCMKINN | QLISSVSNIT | CPDFNPSDCV | 
    2600:
    SGSITYMPNG | CCKTCIPQNQ | TRVPCSAVSV | MKEISYNGCT | KNISMNYCFG | 
    2650:
    SCGTFAMYSA | QVQGLDHRCS | CCKEEKTSVR | SVTLECPDGS | ELSHTYTHIE | 
    2680:
    SCLCQDTVCG | LPQAQQVRTR | RSSPRFLGRK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
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    ELISA Kit for Mouse MUC-2
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    CLIA Kit for Mouse MUC-2
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    CLIA Kit for Mouse MUC-2
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    Packing:
    96T
    CLIA Kit for Mouse MUC-2
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    U0705h
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    96T
    CLIA Kit for Mouse MUC-2
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    U0705r
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    Polyclonal Antibody for Mouse MUC-2
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    P0705Rb-h
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    Packing:
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    Polyclonal Antibody for Mouse MUC-2
    Polyclonal Antibody for Mouse MUC-2
    Cat.:
    P0705Rb-m
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    Packing:
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    Polyclonal Antibody for Mouse MUC-2
    Cat.:
    P0705Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse MUC-2
    Monoclonal Antibody for Mouse MUC-2
    Monoclonal Antibody for Mouse MUC-2
    Monoclonal Antibody for Mouse MUC-2
    Protein for Mouse MUC-2
    Protein for Mouse MUC-2
    Protein for Mouse MUC-2
    Protein for Mouse MUC-2

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1442 AND 1759-2680;TISSUE SPECIFICITY
      strain: C57BL/6J.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-301;TISSUE SPECIFICITY;GLYCOSYLATION
      strain: 129.
      tissue: Colon.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1443-1758 AND 1795-2680
      strain: FVB/N.
      tissue: Colon.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2199-2680
      strain: C57BL/6J.
      tissue: Small intestine.
    5. 5.
      "Colorectal cancer in mice genetically deficient in the mucin Muc2."
      Velcich A. , Yang W. , Heyer J. , Fragale A. , Nicholas C. , Viani S. , Kucherlapati R. , Lipkin M. , Yang K. , Augenlicht L.
      Science295:1726-1729(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    6. 6.
      "The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria."
      Johansson M.E.V. , Phillipson M. , Petersson J. , Velcich A. , Holm L. , Hansson G.C.
      Proc. Natl. Acad. Sci. U.S.A.105:15064-15069(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
    7. 7.
      "Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."
      Johansson M.E.V. , Thomsson K.A. , Hansson G.C.
      J. Proteome Res.8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH FCGBP;SUBCELLULAR LOCATION
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