Protein name:
Mucin-2 (MUC-2) ;
Alternative:
Secreted gel-forming mucin ;Colonic mucin (MCM) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization (By similarity). Interacts with FCGBP. Interacts with AGR2; disulfide-linked.
Function:
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Subcellular Location:
Secreted
In the intestine, secreted into the inner and outer mucus layers.
Protein Attributes:
50:
MGLPLARLVA | ACLVLALAKG | SELQKEARSR | NHVCSTWGDF | HYKTFDGDVY |
100:
RFPGLCDYNF | ASDCRDSYKE | FAVHLKRGLG | EAGGHSQIES | ILITIKDDTI |
150:
YLTHKLAVVN | GAMVSTPHYS | SGLLIEKNDA | YTKVYSRAGL | SLMWNREDAL |
200:
MVELDSRFQN | HTCGLCGDFN | GMQTNYEFLS | EEGIQFSAIE | FGNMQKINKP |
250:
EVQCEDPEAV | QEPESCSEHR | AECERLLTSA | AFEDCQTRVP | VESYVRACMH |
300:
DRCQCPKGGA | CECSTLAEFS | RQCSHAGGRP | ENWRTASLCP | KKCPNNMVYL |
350:
ESSSPCVDTC | SHLEVSSLCE | EHYMDGCFCP | EGTVYDDITG | SGCIPVSQCH |
400:
CKLHGHLYMP | GQEFTNDCEQ | CVCNAGRWVC | KDLPCPETCA | LEGGSHITTF |
450:
DGKKFTFHGD | CYYVLTKSEH | NDSYALLGEL | ASCGSTDKQT | CLKTVVLLTD |
500:
DKKNVVAFKS | GGSVLLNEME | VTLPHVAASF | SIFQPSSYHI | VVNTKFGLRL |
550:
QIQLLPVMQL | FVTLDQAAQG | QVQGLCGNFN | GLESDDFMTS | GGMVEATGAG |
600:
FANTWKAQSS | CHDKLDWLDD | PCSLNIETNY | AEHWCSLLKR | SETPFARCHL |
650:
AVDPTEYYKR | CKYDTCNCQN | NEDCMCAALS | SYARACAAKG | VMLWGWRERV |
700:
CNKDVHACPS | SQIFMYNLTT | CQQTCRSLSE | GDSHCLKGFA | PVEGCGCPDH |
750:
TFMDEKGRCV | PLAKCSCYHH | GLYLEAGDVI | LRQEERCICR | NGRLQCTQVK |
800:
LIGHTCQYPK | ILVDCNNLTA | LAVRKPRPTS | CQTLVAGYYH | TECISGCVCP |
850:
DGLLDDGRGG | CVEEDKCPCI | HNKDLYSSGE | SIKLDCNNTC | TCQKGRWECT |
900:
RYACHSTCSI | YGSGHYITFD | GKHYDFDGHC | SYVAVQDYCG | QNSTGSFSII |
950:
TENVPCGTTG | VTCSKAIKIF | IGGTELKLVD | KHRVVKQLEE | GHHVPYITRE |
1000:
VGQYLVVEAS | SGIIVIWDKK | TTIFIKLDPS | YKGTVCGLCG | NFDDQTKNDF |
1050:
TTRDHMVVTS | ELDFGNSWKE | ASTCPDVSHN | PDPCSLNPHR | RSWAEKQCSI |
1100:
IKSRVFKVCH | SKVDPTVFYE | ACVHDSCSCD | TGGDCDCFCS | AVASYAQECT |
1150:
KAEACVFWRT | PDLCPIFCDY | YNPPDECEWH | YEPCGNRSFE | TCRTLNGIHS |
1200:
NISVSYLEGC | YPRCPEDRPI | YDEDLKKCVT | GDKCGCYIED | TRYPPGGSVP |
1250:
TDEICKSCTC | TNTSKIECHP | DEGKILNMTQ | DGIFCYWEFC | GPNGTVGQHF |
1300:
NICGSSTAIP | STTTSFTTIS | TPISTTPIST | TITTTTVTMT | TEQVPCCFWS |
1350:
DWINKYHPTK | ENGGDRETFT | HVCSAPEDIE | CRAATDPKLS | WEELGQKVQC |
1400:
NVSTGLICNN | EDQYGIGEFE | LCYDYEIRVN | CCYPMEYCTP | STISPTTSTT |
1450:
TLSTTPPTSS | PTTLPTSSPV | TSSATLPTTS | SITSTISPTT | SPSTATQTIS |
1500:
VTTSQTSSSA | TPPNSSPTSS | ATTSPTTSSG | TSTATSPSTS | PTTSSTFTTP |
1550:
PSTTCIDDCK | WTGWLDSGKP | TYDIKSGDFE | LIKGVCEPHW | EVQNISCRAV |
1600:
MHSNIPLDQL | GQIVVCNKEV | GLVCKNEDQE | IGGIIPMRMC | LNYEINVYCC |
1650:
NPICFTSTPS | STTTETPTTT | STTKTSILTS | TTTQTPSPSP | TTTVTPTPAP |
1700:
TTTQIPTSTS | TTTQTTTPTP | ITETSTPTST | ISQTPSPAST | TTVTPATTST |
1750:
TTETSTSTST | TTQTTSPTPT | VTETSTPRST | TTQTPSPVPT | TTVTSTPTPT |
1800:
IGETTTPKRP | PSTSTPTSFT | VPTETTTQTR | PLSTTPTTLE | TTRTSSWGTF |
1850:
SSTSPITSPS | TVWTHTETQV | TCCVLNEMFY | GPGELVYNST | HGGTCFYVNC |
1900:
SLDCHLQFFN | WSCPSTPSTP | TPSTPTPTPS | QTTTPSTTSS | KSTPSTPQST |
1950:
SPKSTLSTPT | KTTPYGCPDF | DPPRQVNETW | WLCNCTMAIC | NHDNVVEIVP |
2000:
LKCDPPPMPT | CANGLKPVRV | PDADNCCWHW | ECDCYCTGWG | DPHFVTFDGL |
2050:
YYSYQGNCTY | VLVEEITPTV | DNFGVYIDNY | HCDANDKVSC | PRTLIVRHET |
2100:
QEVQIKTVRM | MPIEVEVQVN | KQLVALPYKK | YGLEVYESGI | NIVVNISRLE |
2150:
AKISYNGLSF | SIRLPYKLFV | NNTKGQCGTC | TNNTADDCIL | PSGKIISDCE |
2200:
IAADEWLVND | PSKPHCPHKG | LTTKRPATTT | PGLSLNNCTV | SPVCHLIMDS |
2250:
LFSQCHAFVP | PKHYYEACLF | DSCYVPGSNM | ECASVQAYAT | LCAKEGVCID |
2300:
WRNHTQGVCS | VKCPPHKQYQ | ACGPEEEPTC | QPSSSQNSTL | LVEGCFCPEG |
2350:
TTKFAPGYDV | CVKTCGCVGP | DNVPREFGEH | FEFDCKDCVC | REGGSGIVCQ |
2400:
PKKCSGGNQT | TCEEDGTYLV | VETNPDDKCC | NITSCKCDTK | RCKAERPTCL |
2450:
LGFEVKTEIV | PGKCCPVYSC | VPKGVCVHQN | AEYQPGSPVY | SNKCQDCVCT |
2500:
NILDNSTQLN | VISCTHVPCN | ISCSSGFELV | DVPGECCKKC | QQTHCIIEGP |
2550:
KQQYIILKPG | EIHKNPSNKC | TFFSCMKINN | QLISSVSNIT | CPDFNPSDCV |
2600:
SGSITYMPNG | CCKTCIPQNQ | TRVPCSAVSV | MKEISYNGCT | KNISMNYCFG |
2650:
SCGTFAMYSA | QVQGLDHRCS | CCKEEKTSVR | SVTLECPDGS | ELSHTYTHIE |
2680:
SCLCQDTVCG | LPQAQQVRTR | RSSPRFLGRK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Chicken
Rat
ELISA Kit for Mouse MUC-2
ELISA Kit for Mouse MUC-2
ELISA Kit for Mouse MUC-2
ELISA Kit for Mouse MUC-2
Polyclonal Antibody for Mouse MUC-2
Polyclonal Antibody for Mouse MUC-2
Polyclonal Antibody for Mouse MUC-2
Polyclonal Antibody for Mouse MUC-2
Monoclonal Antibody for Mouse MUC-2
Monoclonal Antibody for Mouse MUC-2
Monoclonal Antibody for Mouse MUC-2
Monoclonal Antibody for Mouse MUC-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1442 AND 1759-2680;TISSUE SPECIFICITY
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-301;TISSUE SPECIFICITY;GLYCOSYLATION
strain :
129 .
tissue :
Colon .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1443-1758 AND 1795-2680
strain :
FVB/N .
tissue :
Colon .
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2199-2680
strain :
C57BL/6J .
tissue :
Small intestine .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH FCGBP;SUBCELLULAR LOCATION